Description
Main areas of work
Synthesis and chemical properties of new poly-sulfur and nitrogen-containing heterocyclic compounds, which can be aromatic and antiaromatic, as well as systems with extended conjugation.
Search for components of nonlinear optical materials, electron-rich liquid crystal substances, organic conductors and magnetic materials.
Development of methods for obtaining derivatives of heterocycles containing several sulfur atoms - 1,2,3,4,5-pentathiepins 1,2-dithioles and 1,2,3-dithiazoles, as biologically active substances, possessing, in particular, anti-cancer activity.
Development of methods for the synthesis of sulfur-nitrogen heterocyclic thiazyl radicals and anion radicals, their selenium and tellurium analogues and the creation on their basis of new functional materials - magnetic, magnetic-bistable, electrically conductive and superconducting.
Synthesis of new sulfur-containing heterocyclic systems with potential anticancer activity, based on 1,2-dithiols.
The most important results of fundamental and applied research
New approaches to the synthesis of poly-sulfur-containing heterocycles containing several sulfur atoms and a nitrogen atom based on the reaction of sulfur monochloride complexes and nitrogen-containing bases have been discovered. A number of new heterocyclic systems have been synthesized, including 1,2- and 1,4-thiazines, thiophenes, monocyclic and condensed 1,2-dithiols and 1,2,3-dithiazoles, 1,2,3,4,5-pentathiepins 1,2,3,4,5,6,7-heptathiocanes, etc. The polysulfide-containing heterocyclic compounds obtained by us (1,2-dithiols, 1,2,3,4,5-pentathiepins and 1,2,3-dithiazoles ) show high anti-cancer, antimicrobial and antifungal activities.
The synthesized 1,2,3,4,5-pentathiepins were studied as cathode material for rechargeable batteries; condensed 1,4-dithiins have been proposed as multi-purpose components for photoreceptors.
Scheme 1
A classification of transformations of organic substrates with sulfur monochloride was proposed, which made it possible not only to systematize the previously open reactions, but also to plan the selective synthesis of new sulfur-containing heterocyclic systems from acyclic fragments.
Table 1
Methods for obtaining new heterocyclic systems are proposed: pyrrolo [2 ', 1': 3,4] pyrazino [2,1-b] [1,3] thiazines, 1,2-dithiol-3-ylidene pyridines and 1,2-dithiol 3-ylidenopyrazines, imino-1,3-dithietanes, imino-1,3-thiasetidines and others, based on the transformations of 1,2-dithiols.
